062 * PATIENTS WITH LUPUS ERYTHEMATODES AND ANTIPHOSPHOLIPID SYNDROME UNDERGOING CARDIAC VALVE SURGERY

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Increased morbidity and mortality in patients with antiphospholipid syndrome undergoing valve replacement surgery.

OBJECTIVE Heart valve abnormalities are commonly found in patients with antiphospholipid syndrome but experience with valve replacement in such patients is limited. We analyzed the results of valve replacement in patients with this condition at our institution. METHODS Between 1989 and 2002, 10 patients with antiphospholipid syndrome (8 women, 2 men; aged 38-73 years, mean 49 years) with seve...

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The antiphospholipid syndrome and heart valve surgery.

The antiphospholipid syndrome (APLS) is a complex autoimmune disease often connected to systemic lupus erythematodes. Main features are thromboses, fetal loss and specific antibodies. The involved autoantibodies are directed against plasma proteins such as beta2glycoprotein1 (beta2GPI) or prothrombin which depend on negatively charged phospholipids. Direct antibodies against phospholipids are o...

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Cardiac valve diseases and antiphospholipid syndrome.

Antiphospholipid syndrome (APS) has been recognized as one of the most commontypes of thrombophilia (1). Its main clinical features are arterial/venous thrombosis and pregnancy loss associated with placenta thrombosis. However, other heterogeneous clinical manifestations may be associated with APS, such as thrombocytopenia, haemolytic anemia, neurological impairment and pulmonary hypertension (...

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Libman-Sacks endocarditis in patients with systemic lupus erythematosus with secondary antiphospholipid syndrome

Background: Libman-Sacks endocarditis (LSE) is characterized by sterile lesions that commonly affect the aortic and mitral heart valves. Antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) have been associated with LSE. Cardiac manifestations including LSE could be interrelated with other manifestations and early diagnosis could help in preventing further complications. Case...

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Antiphospholipid syndrome, cardiac surgery and cardiopulmonary bypass.

of APLS are cerebrovascular accident, transient ischemic attack, seizures, chorea, migraine, pseudotumor cerebri, visual disturbances and dementia. Cutaneous features include livedo reticularis, ulcers, infarcts and superficial thrombophlebitis. These patients may develop renal arterial or venous thrombosis, acute or chronic renal failure, hemolytic anemia or thrombocytopenia.[15-17] Catastroph...

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ژورنال

عنوان ژورنال: Interactive CardioVascular and Thoracic Surgery

سال: 2014

ISSN: 1569-9293,1569-9285

DOI: 10.1093/icvts/ivu276.62